ARINDAM TALUKDAR, Ph. D.
Talukdar's lab, lead by Dr. Arindam Talukdar, a Sr. Principal Scientist in CSIR Indian Institute of Chemical Biology, primarily deals with medicinal chemistry. It aims to answer the fundamental questions lying at the interface of chemistry and biology by integrating the concept of organic chemistry, biochemistry and computational explorations for the design and synthesis of novel chemical entities to unravel the molecular mechanism and develop potential treatments for human diseases.​
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Rational design and discovery of potent PROTAC degraders of ASK1: a targeted therapy in MASH
Sarkar HS, Sen A, Hoque I, Ghosh Dastidar U, Pal S, Sarkar D, Chakrabarti P, Arindam Talukdar. RSC Med Chem. 2025, 16, 3469-3494. https://doi.org/10.1039/D5MD00252D
FIRST ORIGINAL RESEARCH ARTICLE ON PROTAC FROM INDIA
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Strategic Design and Optimization of Umifenovir Analogues: Balancing Antiviral Efficacy and hERG Toxicity against SARS-CoV-2
Hoque I, Singh N, Ghosh Dastidar U, Martin AK, Joshi A, Sardana Y, Singh Chawla R, Das N, Patra B, Devi R, Das S, Das D, Kumar S, Ringe RP, Bokara KK, Thakur KG, Arindam Talukdar. Journal of Medicinal Chemistry. 2025, 68(9), 9371.https://doi.org/10.1021/acs.jmedchem.4c03093
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Exploring the Structural Attributes of Yoda1 for the Development of New-Generation Piezo1 Agonist Yaddle1 as a Vaccine Adjuvant Targeting Optimal T Cell Activation
Goon S, Shiu Chen Liu C, Ghosh Dastidar U, Paul B, Mukherjee S, Sarkar HS, Desai M, Jana R, Pal S, Sreedevi NV, Ganguly D, Arindam Talukdar. Journal of Medicinal Chemistry. 2024.
https://doi.org/10.1021/acs.jmedchem.4c00322
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Hit-to-lead optimization of 2-aminoquinazolines as anti-microbial agents against Leishmania donovani. Das N, Roy J, Patra B, Saunders E, Sarkar D, Goon S, Sinha BP, Roy S, Roy S, Sarif J, Bandopadhyay P, Barik S, Mukherjee S, McNamara N, Varghese S, Simpson K, Baell J, McConville M, Ganguly D, Arindam Talukdar. European Journal of Medicinal Chemistry. 2024, 269, 116256.
https://doi.org/10.1016/j.ejmech.2024.116256