Exploring the Structural Attributes of Yoda1 for the Development of New-Generation Piezo1 Agonist Yaddle1 as a Vaccine Adjuvant Targeting Optimal T Cell Activation

Sunny Goon, Chinky Shiu Chen Liu, Uddipta Ghosh Dastidar, Barnali Paul, Suravi Mukherjee, Himadri Sekhar Sarkar, Milie Desai, Rituparna Jana, Sourav Pal, Namala Venkata Sreedevi, Dipyaman Ganguly*, and Arindam Talukdar*. Journal of Medicinal Chemistry. 2024.

 https://doi.org/10.1021/acs.jmedchem.4c00322
 

Hit-to-lead optimization of 2-aminoquinazolines as anti-microbial agents against Leishmania donovani. Das N, Roy J, Patra B, Saunders E, Sarkar D, Goon S, Sinha BP, Roy S, Roy S, Sarif J, Bandopadhyay P, Barik S, Mukherjee S, McNamara N, Varghese S, Simpson K, Baell J, McConville M, Ganguly D*, Arindam Talukdar*. European Journal of Medicinal Chemistry. 2024, 269, 116256. https://doi.org/10.1016/j.ejmech.2024.116256
 

Discovery and Development of Quinazolinones and Quinazolinediones for Ameliorating Nonalcoholic Fatty Liver Disease (NAFLD) by Modulating COP1-ATGL Axis. Sarkar D, Chowdhury S, Goon S, Sen A, Dastidar UG, Mondal MA, Chakrabarti P*, Arindam Talukdar*. Journal of Medicinal Chemistry. 2023, 66, 24, 16728. https://doi.org/10.1021/acs.jmedchem.3c01431
 

EDITORIAL: Catalyzing the Future of Medicinal Chemistry Research in India, Arindam Talukdar*, Sarkar D. Journal of Medicinal Chemistry. 2023, 66, 16, 10868.  https://doi/10.1021/acs.jmedchem.3c01304
 

Development of selective class I protein arginine methyltransferase inhibitors through fragment-based drug design approach. Bhattacharya D, Li ASM, Paul B,  Dastidar UG, Santhakumar V, Sarkar D, Chau I, Li F, Ghosh T, Vedadi M, Arindam Talukdar*.European Journal of Medicinal Chemistry  2023, 260, 115713.   https://doi.org/10.1016/j.ejmech.2023.115713
 

Mitigating hERG Liability of Toll-Like Receptor 9 and 7 Antagonists through Structure-Based Design. Das N, Bhattacharya B, Bandopadhyay P, Dastidar UG, Paul B, Rahaman O, Hoque I, Patra B, Ganguly D*, Arindam Talukdar*. ChemMedChem. 2023, 18, 12, e202300069.

https://doi.org/10.1002/cmdc.202300069
 

Development, Optimization, and In Vivo Validation of New Imidazopyridine Chemotypes as Dual TLR7/TLR9 Antagonists through Activity-Directed Sequential Incorporation of Relevant Structural Subunits. Das N, Bandopadhyay P, Roy S, Sinha BP, Ghosh Dastidar U, Rahaman O, Pal S, Ganguly D*, Arindam Talukdar*.  Journal of Medicinal Chemistry, 2022. https://doi.org/10.1021/acs.jmedchem.2c00386 
 

Hit-to-lead optimization of novel phenyl imidazole carboxamides that are active against Leishmania donovani. McNamara N, Saunders E, Varghese S, Zheng R, Simpson K, Varma DM, Johnson MM, Hasan Zahid MS, Bachelder EM, Ainslie KM, No JH, Koh D, Shum D, Das N, Patra B, Roy J, Arindam Talukdar, Ganguly D, McConville M, Baell J*.  European Journal of Medicinal Chemistry, 2022, 240, 114577. 4026. https://doi.org/10.1016/j.ejmech.2022.114577 
 

Integration of Ligand-Based and Structure-Based Methods for the Design of Small-Molecule TLR7 Antagonists. Pal S*, Ghosh Dastidar U, Ghosh T, Ganguly D, Arindam Talukdar*. . Molecules, 2022, 27, 13, 4026. https://doi.org/10.3390/molecules27134026
 

Topoisomerase I inhibitors: Challenges, progress and the road ahead. Arindam Talukdar, Biswajit Kundu, Dipayan Sarkar, Sunny Goon, Mohabul Alam Mondal. 2022. European Journal of Medicinal Chemistry, 2022, 236, 114304. https://doi.org/10.1016/j.ejmech.2022.114304
 

ICBS 2021: Looking Toward the Next Decade of Chemical Biology. Clinton G.L. Veale, Arindam Talukdar, Boris Vauzeilles. 2022. ACS Chemical Biology. 17, 4, 728–743. https://doi.org/10.1021/acschembio.2c00209
 

Fascinating Transformation of SAM-Competitive Protein Methyltransferase Inhibitors from Nucleoside Analogues to Non-Nucleoside Analogues. Arindam Talukdar, Ayan Mukherjee, Debomita Bhattacharya.  2022. Journal of Medicinal Chemistry. 65, 3, 1662–1684. https://doi.org/10.1021/acs.jmedchem.1c01208
 

Structural Evolution and Translational Potential for Agonists and Antagonists of Endosomal Toll-like Receptors. Arindam Talukdar, Dipyaman Ganguly, Swarnali Roy, Nirmal Das, Dipika Sarkar.  2021. Journal of Medicinal Chemistry.  64, 12, 8010–8041. https://doi.org/10.1021/acs.jmedchem.1c00300
 

Systematic Optimization of Potent and Orally Bioavailable Purine Scaffold as a Dual Inhibitor of Toll-Like Receptors 7 and 9. Biswajit Kundu, Deblina Raychaudhuri, Ayan Mukherjee, Bishnu Prasad Sinha, Dipika Sarkar, Purbita Bandopadhyay, Sourav Pal, Nirmal Das, Debdeep Dey, Kantubhukta Ramarao, Kasireddy Nagireddy, Dipyaman Ganguly, and Arindam Talukdar.  2021. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.1c00532
 

Structural Evolution and Translational Potential for Agonists and Antagonists of Endosomal Toll-like Receptors. Arindam Talukdar, Dipyaman Ganguly, Swarnali Roy, Nirmal Das, Dipika Sarkar. 2021. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.1c00300
 

Synthesis and characterization of new potent TLR7 antagonists based on analysis of the binding mode using biomolecular simulations. Sourav Pal, Barnali Paul, Purbita Bandopadhyay, Nagothy Preethy, Dipika Sarkar, Oindrila Rahaman, Sunny Goon, Swarnali Roy, Dipyaman Ganguly, Arindam Talukdar. 2021. European Journal of Medicinal Chemistry. 

https://doi.org/10.1016/j.ejmech.2020.112978
 

Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain. Gustavo A Bezerra, Alexander Holenstein, William R Foster, Bing Xie, Kevin G Hicks, Céline Bürer, Seraina Lutz, Ayan Mukherjee, Dipika Sarkar, Debomita Bhattacharya, Jared Rutter, Arindam Talukdar, Peter J Brown, Minkui Luo, Lei Shi, D Sean Froese, Wyatt W Yue.  2021. Biochimie. https://doi.org/10.1016/j.biochi.2021.01.007
 

Synthesis and characterization of new potent TLR7 antagonists based on analysis of the binding mode using biomolecular simulations. Sourav Pal, Barnali Paul, Purbita Bandopadhyay, Nagothy Preethy, Dipika Sarkar, Oindrila Rahaman, Sunny Goon, Swarnali Roy, Dipyaman Ganguly*, Arindam Talukdar*.  2021. European Journal of Medicinal Chemistry.

https://doi.org/10.1016/j.ejmech.2020.112978
 

Development of a metabolically stable topoisomerase I poison as anticancer agent. Biswajit Kundu, Dipayan Sarkar, Srijita Paul Chowdhuri, Sourav Pal, Subhendu  K. Das, Benu Brata Das, Arindam Talukdar*.  2020. European Journal of Medicinal Chemistry. https://doi.org/10.1016/j.ejmech.2020.112551. 
 

A Chemical switch for transforming a purine agonist for Toll-like receptor 7 to a clinically relevant antagonist. Ayan Mukherjee, Deblina Raychaudhuri, Bishnu Prasad Sinha, Biswajit Kundu, Mousumi Mitra, Barnali Paul, Purbita Bandopadhyay, Dipyaman Ganguly*, Arindam Talukdar*.  2020. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.0c00011
 

Protective role of ACE inhibitors and ARBs in hypertensive patients suffering from COVID-19. Arindam Talukdar*, Dipayan Sarkar, Subhasis Roy Chowdhury, Dipyaman Ganguly. 2020. 
authorea.com. 

https://doi.org/10.22541/au.158955396.63298622.
 

Emergence of multiple variants of SARS-CoV-2 with signature structural changes. Debaleena Bhowmik, Sourav Pal, Abhishake Lahiri, Arindam Talukdar, Sandip Paul. 2020.  bioRxiv preprint. https://doi.org/10.1101/2020.04.26.062471.
 

Compilation of Potential Protein Targets for SARS-CoV-2: Preparation of Homology Model and Active Site Determination for Future Rational Antiviral Design. Sourav Pal, Arindam Talukdar. 2020. ChemRxiv. https://doi.org/ 10.26434/chemrxiv.12084468
 

Semisynthetic Quercetin Derivatives with Potent Antitumor Activity in Colon Carcinoma.  Ayan Mukherjee, Snehasis Mishra, Kotla Naveen Kumar, Krishnendu Manna; Swarnali Roy, Biswajit Kundu, Debomita Bhattacharya, Krishna Das Saha, Arindam Talukdar. 2019. ACS-Omega. 4 (4), pp 7285–7298. https://doi.org/10.1021/acsomega.9b00143
 

Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poisons with Potent Anticancer Activity.  Biswajit Kundu, Subhendu Kumar Das, Srijita Paul Chowdhuri, Sourav Pal, Dipayan Sarkar, Arijit Ghosh, Ayan Mukherjee, Debomita Bhattacharya, Benu Brata Das, and Arindam Talukdar. 2019. Journal of Medicinal Chemistry. 62 (7), pp 3428–3446. https://doi.org/10.1021/acs.jmedchem.8b01938  
 

Understanding the Riboflavin Biosynthesis Pathway for the Development of Antimicrobial Agents. Biswajit Kundu, Dipayan Sarkar, Namrata Ray, Arindam Talukdar. 2019. Medicinal Research Reviews.

https://doi.org/10.1002/med.21576 
 

Ligand-based Pharmacophore Modeling, Virtual Screening and Molecular Docking Studies for Discovery of Potential Topoisomerase I Inhibitors.  Sourav Pal, Vinay Kumar, Biswajit Kundu, Debomita Bhattacharya, Nagothy Preethy, Mamindla Prashanth Reddy and Arindam Talukdar.2019. Computational and Structural Biotechnology Journal. 17 (2019) 291–310. https://doi.org/10.1016/j.csbj.2019.02.006
 

Activity-guided Development of Potent and Selective Toll-like Receptor 9 Antagonists. Barnali Paul, Oindrila Rahaman, Swarnali Roy, Sourav Pal, Sohal Satish, Ayan Mukherjee, Amrit R. Ghosh, Deblina Raychaudhuri, Roopkatha Bhattacharya, Sunny Goon, Dipyaman Ganguly and Arindam Talukdar. 2018.  European Journal of Medicinal Chemistry.159:187-205. https://doi.org/10.1016/j.ejmech.2018.09.058
 

Cutting Edge: Piezo1 Mechanosensors Optimize Human T Cell Activation. Chinky Shiu Chen Liu, Deblina Raychaudhuri, Barnali Paul, Yogaditya Chakrabarty, Amrit Raj Ghosh, Oindrila Rahaman, Arindam Talukdar and Dipyaman Ganguly. 2018. Journal of Immunology, 200(4). 1255-1260. 29330322. https://doi.org/10.4049/jimmunol.1701118
 

Copper-catalyzed selective C–N bond formation with 2-amino, 2-hydroxy and 2-bromo-5-halopyridine. Swarnali Roy, Barnali Paul, Ayan Mukherjee, Biswajit Kundu and Arindam Talukdar. 2017.  RSC Advances.  7. 44366-44370.  https://doi.org/10.1039/C7RA08482J
 

Design and Development of Benzoxazole Derivatives with Toll-like Receptor 9 Antagonism. Swarnali Roy, Ayan Mukherjee, Barnali Paul, Oindrila Rahaman, Shounak Roy, Gundaram Maithri, Bandaru Ramya, Sourav Pal, Dipyaman Ganguly and Arindam Talukdar. 2017. European Journal of Medicinal Chemistry. 134.  334-347. 28437629. https://doi.org/10.1016-j.ejmech.2017.03.086
 

Arindam Talukdar, Y. Zhao, W. Lv, A. Bacher, B. Illarionov, M. Fischer, and Mark Cushman. O-Nucleoside, S-Nucleoside, and N-Nucleoside Probes of Lumazine Synthase and Riboflavin Synthase. 2012. Journal of Organic Chemistry. 77. 6239-6261. 20373742. DOI: https://doi.org/10.1021-jo1004313.

Abdelrahman S. Mayhoub, Arindam Talukdar, and Mark Cushman. A Highly Efficient Oxidation of Benzyl Methyl Ethers with NBS Selectively Affords Either Aromatic Aldehydes or Aromatic Methyl Esters. 2010. Journal of Org. Chemistry. 75(10), 3507-3510. DOI: 10.1021-jo1004313.
 

Arindam Talukdar, Ekaterina Morgunova; Jianxin Duan; Winfried Meining; Lennart Nilsson; Adelbert Bacher; Boris Illarionov; Markus Fischer; Rudolf Ladenstein; Mark Cushman.Virtual Screening, Selection and Development of a Novel Structural Scaffold for Inhibition of Lumazine Synthase. 2010. Bioorganic Medicinal Chemistry. 18. 3518-3534. DOI: https://doi.org/10.1016/j.bmc.2010.03.072
 

Arindam Talukdar, Meghan Breen, Adelbert Bacher, Boris Illarionov, Markus Fischer, Gunda Georg, Qi-Zhuang Ye, and Mark Cushman. Discovery and Development of a Small Molecule Library with Lumazine Synthase Inhibitory Activity. 2009. Journal of Organic. Chemistry. 74(15), 5123–5134. 19552377. DOI: https://doi.org/10.1021/j0900238q.
 

Arindam Talukdar, Boris Illarionov, Adelbert Bacher, Markus Fischer, and Mark Cushman. Synthesis and enzyme inhibitory activity of the S-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase. 2007. Journal of Organic Chemistry.72. 7167-7175. DOI: https://doi.org/10.1021/jo0709495.
 

Wenlan Chen, Chengfeng Xia, Jinhua Wang, Prakash Thapa, Yusen Li, Arindam Talukdar, Janos Nadas, Wenpeng Zhang, Dapeng Zhou, Peng George Wang. Synthesis and Structure-Activity Relationship Study of Isoglobotrihexosylceramide Analogues. 2007. Journal of Organic Chemistry. 72. 9914-9923. 18020363. DOI: https://doi.org/10.1021/jo701539k.
 

Ha Young Kim, Arindam Talukdar, and Mark Cushman. Regioselective synthesis of N-b-hydroxyethylaziridines by ring-opening reaction of epoxides with aziridine generated in situ. 2006. Organic Letters. 8(6). 1085-1087. DOI: https://doi.org/10.1021/c10529703.
 

Lizhi Zhu, Arindam Talukdar, Guisheng Zhang, James P. Kedenburg, Peng George Wang. A divergent synthesis of uncommon sugars from furanaldehyde. 2005. Synlett, 10. 1547-1550. DOI: https://doi.org/10.1055/s-2005-869846.
 

Gurjar M. K., Arindam Talukdar. Synthesis of terminal disaccharide unit of Klebsiella pneumoniae, 2004. Tetrahedron. 60. 3267-3271. DOI: https://doi.org/10.1016/j.tet.2004.02.017.
 

Arindam Talukdar. Unusual conversion of sugar oximes to sugar nitriles with ruthenium catalysts. 2002. Synthetic Communications. 32(22). 3503.
 

Gurjar M. K., Arindam Talukdar. Heck reaction of (S)-N-Cbz-allyl glycine tert-butyl ester with aromatic halides. 2002. Synthesis. 315.
 

Juneja T. R, Arindam Talukdar, Gupta R. L.Mutagenicity of Sulfoscanate: a comparative study. 2002. Mutation Res. 518. 155-161.
 

Juneja T. R, Arindam Talukdar, Nimish Mehta, Gupta R. L. Effect of various alkyl and unsaturated substituents on the mutagenicity of some nitrophenyl thioethers. 2001. Mutation Res. 495. 97-102. DOI: https://doi.org/10.1016/s1383-5718(01)00201-7.
 

Gurjar M. K., Sadalapure K., Adhikari S., Sarma B. V. N. B. S., Arindam Talukdar, Chorghade M. S. Kinetic resolution of aryl glycidyl ethers: A practical synthesis of optically pure β-blocker (S)-Metoprolol. 1998. Heterocycles. 48. 1471.